Researchers have uncovered new clues to how vitamin D produces health benefits by reducing inflammation associated with such diseases as asthma, arthritis and prostate cancer.

The new study, published in The Journal of Immunology, provides a strong argument for increasing recommended vitamin D levels for patients with such conditions, said Elena Goleva, lead researcher with National Jewish Health.

“This study goes beyond previous associations of vitamin D with various health outcomes,” Govela said. “Patients with chronic inflammatory diseases, such as asthma, arthritis and prostate cancer, who are vitamin D deficient may benefit from vitamin D supplementation [increases].”

Current national guidelines suggest Americans maintain minimum blood levels of 20 nanograms per milliliter of vitamin D. But Goleva said the new research indicates patient levels should be higher – above 30 ng/ml.
Govela’s study examined the ways vitamin D acts on the body’s immune systems and inflammation. They found vitamin D may bind with DNA in cells to block the release of chemicals that promote inflammation.

“This newly identified DNA-binding site [provides] a plausible mechanism for many of the benefits that have been associated with vitamin D,” Goleva said.