Tags: Cold/Flu | flu | vaccine | antibiotics | immune

Antibiotics Hinder Flu Vaccine Effectiveness

By    |   Thursday, 11 Sep 2014 04:12 PM

Antibiotics may cut the effectiveness of the flu shot. That’s the surprising conclusion of new studies involving mice treated with antibiotics to remove most of their gut bacteria or raised under sterile conditions.
 
Emory University researchers found the mice had impaired responses to seasonal influenza shots, suggesting antibiotics should be avoided before or during vaccination.
 
The research, to be published in Immunity by Bali Pulendran, is the latest to indicate gut bacteria affect the body’s immune system and may be a factor in the ability to fight off diseases and infections.
 
"Our results suggest that the gut microbiome may be exerting a powerful effect on immunity to vaccination in humans, even immunity induced by a vaccine that is given at a distant site," said Pulendran, a professor of pathology and laboratory medicine at Emory University School of Medicine and Yerkes National Primate Research Center.
 
Pulendran said researchers are now planning to study the connections between gut bacteria and vaccines in humans.
 
"These results … raise the possibility that the microbiome could be harnessed to modulate vaccine efficacy," said Pulendran. "The key question is the extent to which this impacts protective immunity in humans."

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Antibiotics may cut the effectiveness of the flu shot, according to new studies involving mice treated with antibiotics to remove most of their gut bacteria or raised under sterile conditions.
flu, vaccine, antibiotics, immune
193
2014-12-11
Thursday, 11 Sep 2014 04:12 PM
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