Dr. Gary Small, M.D.

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Gary Small, M.D., is the Director of Behavioral Health Breakthrough Therapies at Hackensack Meridian Health, New Jersey’s largest, most comprehensive and integrated healthcare network. Dr. Small has often appeared on the TODAY show, Good Morning America, and CNN and is co-author (with his wife Gigi Vorgan) of 10 popular books, including New York Times bestseller, “The Memory Bible,” “The Small Guide to Anxiety,” and “The Small Guide to Alzheimer’s Disease.”

Tags: Alzheimers | amyloid | depression | antidepressants
OPINION

Drugs for Mood and Cognition

Dr. Small By Tuesday, 22 May 2018 04:39 PM EDT Current | Bio | Archive

Alzheimer’s disease still has no cure, but there are medicines that can temporarily help with cognitive and behavioral symptoms associated with the disease.

Some of the drugs — Aricept (donepezil), Exelon (rivastigmine), and Razadyne (galantamine) — compensate for a decline in the brain messenger acetylcholine.

Another medication, Namenda (memantine), influences other neurotransmitters and can provide additional cognitive benefits.

These drugs have also been shown to help patients with related disorders, including vascular dementia and dementia with Lewy bodies.

Some patients, especially older ones, suffer from combined mood and cognitive symptoms, which may result from frustration due to cognitive losses.

However, recent research indicates that symptoms of depression may also result from buildup of amyloid plaques and tau tangles, which occur with Alzheimer’s disease.

These patients can experience improved memory with antidepressant medications.

© 2026 NewsmaxHealth. All rights reserved.


Dr-Small
Alzheimer’s disease still has no cure, but there are medicines that can temporarily help with cognitive and behavioral symptoms associated with the disease.
Alzheimers, amyloid, depression, antidepressants
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2018-39-22
Tuesday, 22 May 2018 04:39 PM
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