Question: I take 40 mg of Prilosec every day for acid reflux. Are there any issues with taking magnesium supplements with it?

Dr. Hibberd's answer:
Have you been prescribed Prilosec 40mg by your doctor for long-term treatment? The U.S. Food and Drug Administration (FDA) has informed the public that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year). If you are self-treating with over-the-counter Prilosec for frequent heartburn, inform your doctor if you want to continue for more than 14 days. Prilosec with magnesium is also available for long-term use. Magnesium supplements can provide sufficient amounts of this essential mineral if you don't get enough from food. Different types of magnesium supplements are available, if you want to use as an addition to Prilosec. In one study, magnesium salicylate may have interactions with Prilosec 20 mg, but it is wiser to consult your doctor before taking magnesium salicylate with the 40 mg dosage of Prilosec.