Question: Is there any real difference between ibuprofen, aspirin, and acetaminophen for a headache?

Dr. Hibberd's answer:

Yes. Painkillers are different.

For instance, migraine sufferers will find that 1000 milligrams of aspirin as a single dose may be as effective as a shot of prescription migraine medication. Unfortunately, ibuprofen and Tylenol do not have that same effect.

But Tylenol (650 mg) and ibuprofen (200 mg) are usually sufficient to treat the average non-migraine headache. Some NSAID medications (such as ibuprofen) may cause rebound headaches in migraine sufferers, so consult your physician for guidance on treating the type of headaches you have.

Remember that in medicine, a higher dose does not always mean more benefit; sometimes it simply means more side effects. Generally, unless guided by your physician otherwise, stick to the printed directions on your medicine bottles.