Question: I’m a kidney transplant patient and two-time cancer survivor. Since I’ve had my kidney transplant and am finally starting to get back on my feet again, I am getting chronic muscle weakness. If I walk more than 100 yards, the muscles in my legs start to cramp and I have to stop walking and rest. I am not out of breath, but my muscles hurt. I have seen several doctors and none think my anti-rejection medications are causing it. I’m looking for some kind of hope. My growth hormone is low, my muscles are small and I weigh 97 pounds, but why the muscle problem?

Dr. Hibberd's Answer:

As a kidney transplant patient, you are on a number of medications and potent immune suppressants, all of which can cause your muscle complaints. These muscle complaints would normally be present at rest and on exertion. Muscle pain on exertion is suggestive of de-conditioning, vascular compromise to muscle, or muscular atrophy or dystrophy. See your personal physician and bring this to their attention for immediate evaluation and investigation.

You are correct in looking further with these new symptoms. Vascular disease is often accelerated in post transplant patients, so you are correct in looking further with these new symptoms. The position of your transplanted kidney in your pelvis/lower abdomen may somehow be playing into your symptoms by subtle obstruction or restriction of circulation when walking. This can be readily visualized by ultrasound complemented by CTT or MRI scanning. Let me know your findings.
By the way, growth hormone (GH) normally decreases as we age, and as long as you are not deficient, replacement to youthful levels is not usually advisable.