Diabetics who suffer serious complications are more likely to have defects in two genes, according to new research that points the way to new genetic therapies that might combat those conditions.

The findings — by researchers from the University of Turin, Italy, the University of Helsinki, and Folkhälsan Research Centre, Finland — indicate mutations on the so-called SLC19A3 gene which governs the transfer vitamin B1 into cells are linked to diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy.

To reach their conclusions, the team tracked the medical records and genetic makeup of a large group of Type 1 diabetes patients.

"Based on these results, it seems that the SLC19A3 gene has a role in the development of diabetic nephropathy and diabetic retinopathy. The results also help explain why some patients with type 1 diabetes are more likely to develop complications than others," said researcher Iiro Toppila. "However, further research is needed into the biological effects of point mutations."