Tags: skin cancer | vaccine | experimental | moderna | merck | recurrence | death

Skin Cancer Vaccine Reduces Recurrence, Death Risk

doctor examining mole on patient
(Dreamstime)

Tuesday, 20 January 2026 09:01 AM EST

Moderna ⁠and Merck said on Tuesday their experimental vaccine for a serious type of skin cancer, when used with Keytruda, reduced the ‍risk of recurrence or death ‍by 49% in a mid-stage trial based on five years of ⁠follow up.

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The improvement in recurrence-free survival was consistent with data reported at ​the three-year mark in 2023.

The vaccine, called intismeran autogene, was being tested in patients with ‍high-risk melanoma who had their tumors surgically removed. ⁠It is designed specifically for each patient based on the unique genetic signature of their tumor.

The treatment works by training ⁠the immune ​system to recognize and ⁠attack cancer cells. When given with Keytruda, ‍an immunotherapy drug that removes brakes on the immune ‌system, the combination aims to both activate and sustain the body's cancer-fighting response.

Moderna and ⁠Merck are ​now running ‍eight larger studies testing the combination treatment in different types of ‍cancer, including lung, bladder and kidney. 

© 2026 Thomson/Reuters. All rights reserved.


Health-News
Moderna ⁠and Merck said on Tuesday their experimental vaccine for a serious type of skin cancer, when used with Keytruda, reduced the risk of recurrence or death by 49% in a mid-stage trial based on five years of ⁠follow up.The improvement in recurrence-free survival was...
skin cancer, vaccine, experimental, moderna, merck, recurrence, death
173
2026-01-20
Tuesday, 20 January 2026 09:01 AM
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