Pope Leo's four-nation Africa tour featured firm denunciations by the pontiff of despotism and war and also attacks from President Donald Trump that grabbed headlines.
But a smaller moment, in which the Pope said the Catholic Church should prioritize questions of inequality and justice over those of sexual ethics, may prove to be of longer-lasting importance for the Church's 1.4 billion members, said experts.
"The unity or division of the Church should not revolve around sexual matters," Leo, the first U.S. Pope, said in a press conference on his flight home on Thursday, answering a question about how the Church considers same-sex marriage.
"I believe there are much greater and more important issues such as justice, equality ... that would all take priority before that particular issue," he said.
Marianne Duddy-Burke, executive director of Dignity USA, a group that supports LGBTQ Catholics, called the Pope's remarks "a very significant and overdue reorientation of priorities."
Priests and bishops in the global Church have long emphasized as high priorities its teachings on sexual issues, including its bans on abortion, birth control, and same-sex marriage.
On his first trip to Africa in 2009, the late Pope Benedict XVI sparked an international outcry when he said the Church could not relax its ban on Catholics using condoms, even to help fight the transmission of HIV/AIDS.
Benedict said allowing condoms would only "increase the problem" ethically.
Leo made his comments on Thursday in response to a question about the Church offering blessings for same-sex couples. He said he supported a landmark 2023 decision by the late Pope Francis allowing pastors to give blessings to same-sex couples informally, outside of a ritual service, and on a case-by-case basis.
But Leo said he wanted to prioritize other ethical questions and did not want the blessings to be formalized further.
"To go beyond that today, I think that the topic can cause more disunity than unity," said the 70-year-old pontiff.
Rev. James Keenan, an academic at Boston College, called Leo's approach new for the global Church.
The Pope is "stating that the Vatican has a hierarchy of concerns and the perception that matters of sexuality have singular priority of place is not the case," said Keenan, a Jesuit priest who founded a global network of Catholic academics focused on ethical issues.
"This is clearly a prudential judgment by the pontiff ... that issues of blessing gay marriage ought not eclipse more immediate challenges of dictatorships and war," said Keenan.
The Catholic Church teaches that sexual relationships outside heterosexual marriage are sinful. It says people with same-sex attractions should try to be chaste.
Francis, who led the Church for 12 years until his death last April, largely also sought to emphasize the Church's teachings on justice issues.
Asked in 2013 about rumors surrounding a priest working at the Vatican being gay, Francis famously responded: "If a person is gay and is seeking the Lord and has good will, who am I to judge them?"
Those remarks, signaling unprecedented openness from a Pope toward LGBTQ Catholics, became a seminal moment in Francis' tenure, quoted widely and printed on merchandise and T-shirts.
"This seems like Leo's 'Who am I to judge?' moment," said David Gibson, a Vatican expert and academic at Fordham University, about Leo's Thursday remarks.
"(Leo) is about peace and justice and sees those moral teachings as equally important as sexual ethics," said Gibson.
Francis DeBernardo, executive director of New Ways Ministry, another group that supports LGBTQ Catholics, praised Leo's response.
"He listed other matters, more social matters -- justice, equality, freedom -- as being of greater moral concern," said DeBernardo. "For years, Catholic advocates for LGBTQ+ people have been saying the same thing."
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