Tags: gilead | kite pharma | cancer | megadeal

Gilead to Buy Kite Pharma in Cancer Drug Megadeal

Image: Gilead to Buy Kite Pharma in Cancer Drug Megadeal

This July 9, 2015, file photo shows the headquarters of Gilead Sciences in Foster City, Calif. (AP Photo/Eric Risberg, File)

Monday, 28 August 2017 01:48 PM

Gilead Sciences Inc. will buy Kite Pharma Inc. for about $11.9 billion, making one of its biggest-ever deals for a breakthrough new cancer treatment and helping it diversify away from its eroding franchise of medicines for hepatitis C infections.

With Kite, Gilead will gain a foothold in one of the most promising fields in oncology: treatments known as CAR-T that re-engineer the body’s own immune system to fight tumors. The drugmaker said Monday that it will pay $180 a share in an all-cash deal. That’s 29 percent above the Friday closing price for Santa Monica, California-based Kite.

“This is a pivot to cellular therapy as our main strategy going forward,” Gilead Chief Executive Officer John Milligan said on a call with analysts. The company, which hasn’t had great success in cancer so far, will continue to look for assets. “We’re not going quiet after this deal.”

The acquisition caps more than a year of search as valuations for biotechnology companies focused on breakthrough therapies soared and the best got bought by rivals. Gilead, seeking to fill a gap left by declining sales of hepatitis C medicines, said last year it was feeling “an urgency to look at external opportunities.”

Gilead was ready to pay the price for Kite, whose shares have tripled just this year. Among Kite’s most-anticipated new treatments is a drug for non-Hodgkin lymphoma, which is awaiting for U.S. approval. Kite said this month it could be ready for a launch as soon as September, sending the shares new records. Kite is racing Swiss giant Novartis AG to get its first product on the market.

Gilead shares rose 0.6 percent to $74.21 at 9:19 a.m. before the U.S. markets opened. Kite jumped to $179.90. The Kite deal also sent peers including Juno Therapeutics Inc. soaring.

The Kite acquisition also signals an evolution in Gilead’s thinking about CAR-T as pressure from investors grew to make a deal and some biotechs, including Kite, showed very effective results in trials. As recently as last year, CEO Milligan expressed some skepticism about the therapies, saying they’re complex and labor-intensive -- more like a bone marrow transplant than a drug.

Because they harness the body’s own immune system, CAR-Ts have had dramatic results in trials for some patients, but also showed strong and sometimes lethal side effects with others. CAR-T are also complex to manufacture. Unlike pills or chemotherapy, the treatments can’t be stockpiled. They’re living drugs, and the production process entails drawing a patient’s blood; extracting the T-cells; inserting a gene that will enable them to identify tumors as targets; then infusing the cancer-killing compound back into the patient at a specialized medical center.

But Gilead watched Kite becoming more and more attractive through the summer, Milligan said Monday.

“It became clear that the side effects would be more manageable and more importantly that the manufacturing would work,’’ Milligan said. “They’ve solved the manufacturing problem. It all added up to this being a very unique, special opportunity for us, and this became very compelling.”

The transaction, scheduled to close in the fourth quarter, would be Gilead’s largest by equity value, surpassing the 2012 acquisition of Pharmasset for $11.2 billion. The Kite agreement was unanimously approved by the two boards and will start add to earnings three years after completion.

BofA Merrill Lynch and Lazard advised Gilead, while Centerview Partners provided advice to Kite, along with Jefferies LLC and Cowen & Co. For legal counsel, Gilead was advised by Skadden, Arps, Slate, Meagher & Flom served as legal counsel to Gilead, while Sullivan & Cromwell LLP and Cooley LLP counseled Kite.

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Gilead Sciences Inc. will buy Kite Pharma Inc. for about $11.9 billion, making one of its biggest-ever deals for a breakthrough new cancer treatment and helping it diversify away from its eroding franchise of medicines for hepatitis C infections.
gilead, kite pharma, cancer, megadeal
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2017-48-28
Monday, 28 August 2017 01:48 PM
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