Tags: Alzheimer's/Dementia | alzheimers | progression | aspirin

Alzheimer's Progression May Be Slowed by Common Aspirin

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By    |   Tuesday, 03 July 2018 12:20 PM

Alzheimer's disease progression may be slowed by over-the-counter, low-dose aspirin that helps to clear cellular debris in the brain, a study released on Monday said.

According to a Society for Neuroscience release, the research presents a new avenue of study for reducing Alzheimer's pathology. The study published in JNeurosci details results from using a mouse model.

Dr. Kalipada Pahan, a professor of neurological sciences, biochemistry and pharmacology at the Rush University Medical Center in Chicago, and colleagues, showed in the study how common aspirin appeared to decrease amyloid plaque pathology in mice by stimulating lysosomes, the component of animal cells that help clear cellular debris.

The research noted that aspirin is already used for pain relief and for the treatment of cardiovascular diseases.

"Understanding how plaques are cleared is important to developing effective drugs that stop the progression of Alzheimer's disease," Pahan said in a Rush University Medical Center release.

The study found that aspirin augmented a protein called TFEB, considered the master regulator of waste removal, by stimulating lysosomes that decreased amyloid plaque pathology in the mice.

"More research needs to be completed, but the findings of our study have major potential implications for the therapeutic use of aspirin in (Alzheimer's disease) and other dementia-related illnesses," Pahan said.

Though the exact cause of Alzheimer's disease progression is unknown, poor disposal of the toxic protein amyloid beta in the brain is a leading mechanism in dementia and memory loss, the study said.

Alzheimer's disease is a progressive form of dementia that affects up to one in 10 Americans age 65 or older.

According to the Centers for Disease Control and Prevention, as many as five million Americans were living with Alzheimer's disease in 2013, but that number is expected to nearly triple to 14 million by 2050. The CDC said the number of people living with Alzheimer's doubles every five years beyond age 65.

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Alzheimer's disease progression may be slowed by over-the-counter, low-dose aspirin that helps to clear cellular debris in the brain, a study released on Monday said.
alzheimers, progression, aspirin
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2018-20-03
Tuesday, 03 July 2018 12:20 PM
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