Tags: Breakthrough | Combo | For | Endometrial | Cancer

Breakthrough Combo For Endometrial Cancer

Tuesday, 06 December 2005 12:00 AM

The combination of doxorubicin and cisplatin given after surgery is very effective against advanced endometrial cancer, according to a new study at East Carolilna University.

The drugs cut the risk of recurrence by 29 percent and extended survival by 32 percent, according to the nine-year, 400-woman study led by Dr. Marcus Randall.

Endometrial cancer is the most common cancer of the female reproductive tract. According to the NCI, there are about 40,000 new cases of endometrial cancer in the U.S. every year and 7,000 deaths

"This study represents a major advance in the treatment of advanced endometrial cancer," declared University of Chicago expert Dr. Gini F. Fleming in an editorial published along with the research in the Journal of Clinical Oncology.

After five years, 50 percent of the women who received chemotherapy were cancer-free and 55 percent were still alive, the researchers noted. Among the women who received the radiation therapy, 38 percent were cancer-free and 42 percent were alive after five years.

However, there was a downside - the drugs caused serious side effects, including reduced blood cell counts, and trouble with the digestive and nervous systems.

"Future trials need to address treatment of earlier-stage disease, optimization of chemotherapy regimen, integration of radiotherapy, and application of newer targeted agents," Dr. Fleming said.

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The combination of doxorubicin and cisplatin given after surgery is very effective against advanced endometrial cancer, according to a new study at East Carolilna University. The drugs cut the risk of recurrence by 29 percent and extended survival by 32 percent,...
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2005-00-06
Tuesday, 06 December 2005 12:00 AM
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