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Ibuprofen and Infertility in Men Linked by Study

Ibuprofen and Infertility in Men Linked by Study

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By    |   Tuesday, 09 January 2018 12:40 PM

Ibuprofen may be linked to male infertility, a study has found, and although the effects were reversible the long-term effects are unknown.

Researchers conducted a relatively small study that included men aged 18 to 35 and found that those who used the common over-the-counter drug developed hormonal imbalances that can cause a reduction in fertility, CBS news reported.

Researchers published their findings in the Proceedings of the National Academy of Sciences, noting that consumption of ibuprofen resulted in “compensated hypogonadism," a condition in which men have normal levels of testosterone but higher levels of the luteinizing hormone, which stimulates the production of testosterone, The International Study for Sexual Medicine said.

This condition is prevalent in elderly men and is associated with reproductive and physical disorders.

The study involved 31 men, 14 of which were given a daily dose of 600 milligrams ibuprofen twice a day – the amount commonly consumed by athletes, CBS News reported.

The other 17 men were administered a placebo and, within 14 days, those taking ibuprofen had developed the hormonal condition.

Researchers told CNN that, while these effects were reversible, they were unsure of whether there were long-term health effects associated with the prolonged use of ibuprofen.

Erma Z. Drobnis, an associate professional practice professor of reproductive medicine and fertility at the University of Missouri, said the effects that drugs have on male fertility are rarely evaluated before marketing.

“Prescribing providers rarely mention these adverse effects with patients when prescribing these medications,” she said, according to CNN, noting that the study was “important” and that the use of ibuprofen could have a far greater negative effect on men who already have low fertility.

The Consumer Healthcare Products Association, a trade group representing the manufacturers of over-the-counter medications, said it was in support of such research and efforts made to educate consumers.

“The safety and efficacy of active ingredients in these products has been well documented and supported by decades of scientific study and real-world use,” said Mike Tringale, a spokesman for the association, according to Fox News.

Drobnis called for larger clinical trials to be performed, saying that future efforts should “raise awareness of medication effects on men and potentially their offspring,” CNN reported.

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Ibuprofen may be linked to male infertility, a study has found, and although the effects were reversible the long-term effects are unknown.
ibuprofen, male, infertility, link
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2018-40-09
Tuesday, 09 January 2018 12:40 PM
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