Tags: Health Topics | Cancer | topical | chemo | spray | intravenous | therapy

Topical 'Chemo Spray' Could Replace Intravenous Therapy

Topical 'Chemo Spray' Could Replace Intravenous Therapy
(Tyler Olson/Dreamstime.com)

By    |   Wednesday, 15 August 2018 12:22 PM

Topical “chemo spray” could eventually replace intravenous therapy as an effective treatment for cancer, being administered directly onto the tissue surface near a tumor site and sidestepping a wide range of adverse side effects, said a new study reported on by Phys.org.

Chemotherapy is most commonly administered intravenously, but because the drug travels throughout the body it can damage healthy cells and cause severe side effects ranging from hair loss and fatigue to nausea, vomiting, weight loss and anemia, according to The American Cancer Society.

Researchers led by Hyung Joon Cha at Pohang University of Science and Technology in South Korea, detailed in a paper appearing in a recent issue of ACS Nano how they may have figured out how to counteract these effects.

The topical spray contains a chemotherapy drug such as doxorubicin, which is encapsulated in nanoparticles that can efficiently be absorbed primarily by cancer cells yet does not impact healthy cells. The spray offers a much lower risk of systematic toxicity.

To develop the treatment, researchers first had to figure out how to get the nanoparticles to stick to the outside of the tumor cells, which are surrounded by bodily fluid.

Drawing inspiration from nature, they bioengineered an adhesive that mimicked what is found on marine mussels, which allows them to stick to wet rocks.

The recreated muscle adhesive proteins enabled the drug-carrying nanoparticles to stick to wet porcine skin tissue for several weeks and also enter and destroy cancer cells.

"The mussel adhesive protein-based sprayable sticky nanoparticles not only facilitate site-directed administration of drugs via a convenient spraying process during the surgical procedure, but also induce an effective anticancer effect based on the significantly enhanced drug retention and absorption efficiency in the cancerous lesion," Cha told Phys.org.

"Therefore, our nanoparticle-based localized drug delivery system can compensate for the disadvantages of low drug delivery efficiency and systemic toxicity in systemic delivery system."

© 2019 Newsmax. All rights reserved.

   
1Like our page
2Share
TheWire
Topical “chemo spray” could eventually replace intravenous therapy as an effective treatment for cancer, being administered directly onto the tissue surface near a tumor site and sidestepping a wide range of adverse side effects, said a new study.
topical, chemo, spray, intravenous, therapy
316
2018-22-15
Wednesday, 15 August 2018 12:22 PM
Newsmax Media, Inc.
 

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

NEWSMAX.COM
© Newsmax Media, Inc.
All Rights Reserved