Patrick has been researching and writing about breakthrough tech for over 30 years. He has written over 200 editorials for USA Today. He has appeared in the Wall Street Journal and on CNN’s Crossfire news program.

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Tags: Alzheimers | oxaloacetate | glutamate | beta-amyloid

New Promise in Alzheimer's Fight

By Friday, 02 September 2016 12:46 PM Current | Bio | Archive

Oxaloacetate is a naturally occurring molecule that plays a vital role in mitochondrial function. A recent study published in the Oxford journal “Cerebral Cortex” bolsters similar research showing that oxaloacetate protects brain health in animals.

Human oxaloacetate studies using this compound (marketed as benaGene) are taking place at the University of Kansas Medical Center.

These trials should either confirm or disprove the theory that this compound helps prevent aging of the brain.

In the meantime, we have very impressive animal data.

The title of the latest study is “Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid-Beta and TNF Alpha- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus.”

Basically, that means the physical markers and symptoms of Alzheimer’s disease can be reduced by normalizing glutamate levels in animal brains.

Glutamate is a neurotransmitter responsible for turning on the electrochemical switches that send signals between neurons. Neuronal signaling allows us to think, learn, and remember.

But too much glutamate can increase amyloid-beta levels and reduce the ability of neurons to function optimally. This is true in humans as well as lab rats.

That’s why pharmaceutical companies have invested fortunes looking for ways to reduce glutamate levels.

The "Cerebral Cortex" study shows that oxaloacetate produces glutamate homeostasis in animal brains. This protects the ability to learn or long-term potentiation (LTP).

This is not the first animal study to show that oxaloacetate protects LTP, but it brings new insight into how it works

Other research has demonstrated oxaloacetate’s anti-aging benefits in animals via improvement in mitochondrial function. This includes increased production of adenosine triphosphate (ATP), the energy our bodies actually run on.

Oxaloacetate also seems to assist in the activation of gene pathways that have to do with the metabolic benefits of calorie restriction.


Clearly, you should decide for yourself whether to use oxaloacetate.


Even though I have genes that are supposed to protect me from Alzheimer’s, I still take it… mainly because of its anti-aging potential.


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Oxaloacetate is a molecule that plays a vital role in mitochondrial function. A recent study published in the Oxford journal “Cerebral Cortex” bolsters research showing that oxaloacetate protects brain health in animals.
Alzheimers, oxaloacetate, glutamate, beta-amyloid
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2016-46-02
Friday, 02 September 2016 12:46 PM
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