Tags: thiabendazole | cancer | drug

Antifungal Drug Found to Kill Tumors

Thursday, 23 Aug 2012 09:26 AM


An inexpensive antifungal drug has been found to be a potent weapon against tumors – substantially slowing the growth of cancer cells – and shows promise as a new chemotherapy for cancer.
Scientists in the College of Natural Sciences at the University of Texas at Austin made the discovery in laboratory tests of mice treated with the drug, thiabendazole, that they said have significant implications for people, too.
Thiabendazole is an Food and Drug Administration-approved, generic drug in clinical use for 40 years as an antifungal. It is not currently used for cancer therapy. The team’s research, published in the Public Library of Science journal PLOS Biology, found the drug works against tumors by destroys newly established blood vessels that feed their growth – making it a "vascular disrupting agent" that essentially starves cancer cells.
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"This is very exciting to us, because in a way we stumbled into discovering the first human-approved vascular disrupting agent," said researcher Edward Marcotte, professor of chemistry. "Our research suggests that thiabendazole could probably be used clinically in combination with other chemotherapies."
In trials involving mice, the researchers found that the drug decreased blood vessel growth in tumors by half and also slowed cancer cell growth. Tests of the drug on human blood vessel cells also found it blocks the growth of tumors.
The scientists' now hope to test drug into clinical trials in patients.
"We hope the clinical trials will be easier because it is already approved by the FDA for human use," said Marcotte.
The study was funded, in part, by the National Institutes of Health.
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An inexpensive antifungal drug has been found to be a potent weapon against tumors.
thiabendazole,cancer,drug
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2012-26-23
Thursday, 23 Aug 2012 09:26 AM
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