Tags: hdl | heart | disease | cholesterol

Raising HDL Doesn’t cut Heart Risks

Wednesday, 23 May 2012 10:46 AM


New genetic research is challenging the long-held belief that raising a person's HDL "good” cholesterol lowers the risk of a heart attack.
The study, published in the Lancet, found people with genes that give them naturally higher HDL levels have no reduced risk of heart disease than those who have slightly lower levels.
To reach their conclusions, researchers from Harvard Medical School, the Massachusetts Institute of Technology and Massachusetts General Hospital examined the effects of 15 naturally occurring genetic variations in 170,000 people that raise their HDL levels.
But they found the HDL-boosting genetic variations do not reduce the risk of heart attack.
"It's been assumed that if a patient, or group of patients, did something to cause their HDL levels to go up, then you can safely assume that their risk of heart attack will go down," said researcher Sekar Kathiresan, director of preventive cardiology at MGH and professor of medicine at Harvard. "This work fundamentally questions that."
Each of the genetic variants Kathiresan and his colleagues studied reflects distinct ways the body might raise HDL. But they suggested developing drugs to boost the action of those genes may not make sense, based on their findings.


© HealthDay

   
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A new study challenges the belief that raising "good” cholesterol lowers the risk of a heart attack.
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2012-46-23
Wednesday, 23 May 2012 10:46 AM
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