Tags: diabetes | drug | effective | tak | 875

New Diabetes Drug Effective

Monday, 27 Feb 2012 03:24 PM


A new diabetes drug is as effective as a longtime standby, but carries a far lower risk of a side effect the older drug can sometimes pose -- creating a dangerous drop in blood sugar – new research shows.
TAK-875 -- a new treatment for type 2 diabetes – was found to improve blood sugar control was well as glimepiride, but does not pose a risk of hypoglycemia, according to a new study published online in The Lancet.
Type 2 diabetes accounts for 90 percent of the 150 million U.S. cases of the disease. It is primarily caused by a lack of response to insulin which leads to high blood sugar and a variety of chronic conditions.
TAK-875, an oral medication, is designed to enhance insulin secretion when it’s needed, but has no effect when blood-sugar levels are normal, without the risk of hypoglycemia.
The new study, led by Dr. Charles Burant , of the University of Michigan Health System, involved 426 patients with type 2 diabetes. They were divided into several groups – one of which received TAK-875. The others were given a placebo (a dummy pill), or glimepiride, a conventional diabetes treatment.
At 12 weeks, patients taking the TAK-875 and glimepiride resulted in significant drops in a standard measure of blood sugar, compared with those given a placebo.
But the incidence of hypoglycemia was significantly lower for patients taking TAK-875 compared with glimepiride (2 percent compared to 19 percent), and was similar to placebo which was 2 percent.
“The low-risk of hypoglycemia after treatment with TAK-875 suggests that there may be therapeutic advantage of [its use] in treating people with type 2 diabetes,” the authors wrote. “We are truly excited about the potential of TAK-875 and are eager to conduct larger trials to find out how well this drug works, how safe it is and what its place is in the treatment of diabetes.”
The researchers noted Burant is an unpaid consultant and advisor to Takeda Global Research and Development, which discovered TAK-875.


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Clinical trials of a new diabetes drug, TAK-875, find it as effective as a longtime medicine of choice.
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2012-24-27
Monday, 27 Feb 2012 03:24 PM
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