Tags: blood | pressure | cancer | lip | drugs | hypertension

Blood Pressure Meds Tied to lip Cancer

Wednesday, 08 August 2012 11:32 AM

Long-term use of common blood pressure medications may reduce the risk of heart problems, but also increases sensitivity to sunlight – boosting the odds of developing lip cancer, new federally funded research shows.
The Kaiser Permanente study, published online in the Archives of Internal Medicine, found that antihypertensive drugs such as nifedipine and hydrochlorothiazide were associated with squamous cell lip cancer.
"Lip cancer remains rare and an increased risk of developing it is generally outweighed by the benefits of these blood pressure drugs and other photosensitizing medications," said lead researcher Dr. Gary Friedman, with the Kaiser Permanente Northern California Division of Research.
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"Physicians prescribing photosensitizing drugs should ascertain whether patients are at high risk of lip cancer by virtue of fair skin and long-term sun exposure and discuss lip protection with them. Although not yet confirmed by clinical trials, likely preventive measures are simple: a hat with sufficiently wide brim to shade the lips and lip sunscreens."
For the study, researchers compared 712 non-Hispanic white patients in Northern California with lip cancer to 22,904 other people without cancer over a 14-year period. They found that the risk of lip cancer was higher for long-term users of blood pressure medications. Photosensitizing drugs are believed to absorb energy from ultraviolet rays, causing the generation of free radicals that damage DNA and produce an inflammatory response in skin cells, Friedman said.
The study was funded by the National Cancer Institute.
SPECIAL: This Small Group of Doctors are Quietly Curing Cancer — Read More.

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Long-term use of blood pressure drugs has been found to raise the odds of developing lip cancer.
Wednesday, 08 August 2012 11:32 AM
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