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Key to Successful Weight Loss: Your Genes and Key 'Markers'

Key to Successful Weight Loss: Your Genes and Key 'Markers'
(Copyright DPC)

Wednesday, 03 January 2018 11:35 AM

If you can’t seem to lose weight, your genes might be the real culprit.

That’s the upshot of a new study involving 46 people who took part in an eight-week program that involved dietary changes, exercise, and other healthy behaviors at a Veterans Affairs facility.

Researchers found that some people who participated in the program shed pounds, but others did not. The difference?

It turns out variations in participants’ genes may have accounted for who lost weight, and who didn’t, reports the Live Science Website.

The participants submitted a DNA sample for a test called PathwayFIT, made by the company Pathway Genomics, which funded the study.

Pathway, one of the nation’s most respected genetic testing companies, analyzed 75 genetic markers linked with certain health conditions or with the body's responses to diet and exercise.

When researchers compared the DNA of those individuals who had lost 5 percent or more of their body weight with those who lost less than 1 percent (or gained weight), they found five genetic markers linked with weight loss.

They concluded the markers could predict who would successfully lose weight with 75 percent accuracy.

"Patient weight loss following behavioral modification therapy really varies," said study author Cecilia Dalle Ore, a medical student at the University of California-San Diego.

The findings – presented at Digestive Disease Week, a scientific meeting focused on digestive diseases, in May 2016 – suggest that people's genes could potentially be used to predict their response to behavioral modification programs.

Researchers noted that because the study was small, involving fewer than four dozen people, future research is necessary to confirm the findings.

Dr. Amir Zarrinpar, a gastroenterologist at UCSD and a senior author of the study, says such tests may be a key way for helping patients lose weight.

"By validating these types of genetic tests and showing that they apply to a general population, we can try to improve patient weight loss treatments. For example, instead of waiting three months to see whether a patient is going to respond or not, you could use this kind of information to say, 'OK, we know this patient's likelihood of succeeding is going to be low. Let's do something else instead,'" Zarrinpar said. "That's what we're going towards."

Pathway Genomics markets a genetic test called PathwayFIT that not only helps you set diet guidelines for weight loss, but gives you genetic details of your food allergies and what type of exercises work best for your body. Find out more info on Pathway at Pathway.com.

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Can't seem to lose weight no matter how much you exercise and eat right? It could be your genes are to blame. That's the upshot of new study findings that suggest genetic 'markers' may help identify who benefits, and doesn't, from conventional weight loss programs.
weight, loss, genes, obesity
Wednesday, 03 January 2018 11:35 AM
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