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Study: 'Trojan Horse' Drug Tricks, Kills Cancer Cells

Study: 'Trojan Horse' Drug Tricks, Kills Cancer Cells
(AP)

By    |   Sunday, 21 July 2019 03:19 PM

Attaching cancer-killing medicine to fatty acids, researchers say they have found their "Trojan horse" in targeting cancerous tumors in humans, according to a report on the research.

"It's like a Trojan horse," lead researcher Nathan Gianneschi explained in a statement. "It looks like a nice little fatty acid, so the tumor's receptors see it and invite it in. Then the drug starts getting metabolized and kills the tumor cells."

The study was published this week in the Journal of the American Chemical Society, noting the "Trojan horse" tale of Greeks sneaking into the ancient city of Troy in a wooden horse disguised as a gift. 

The chemotherapy drug called paclitaxel tricks tumors into inviting the medicine-carrying fatty acid in before the medicine activates and kills the targeted cells. The revelation lowers toxicity to the patient and causes less harmful side effects than most currently approved chemotherapy treatments, according to the report.

"Commonly used small-molecule drugs get into tumors — and other cells," Gianneschi's statement reads, per the report. "They are toxic to tumors but also to humans. Hence, in general, these drugs have horrible side effects. Our goal is to increase the amount that gets into a tumor versus into other cells and tissues. That allows us to dose at much higher quantities without side effects, which kills the tumors faster."

In animal testing, the strategic medicine eliminated bone, pancreatic, and colon cancers.

"It's like the fatty acid has a hand on both ends: one can grab onto the drug and one can grab onto proteins," Gianneschi's statement adds. "The idea is to disguise drugs as fats so that they get into cells and the body is happy to transport them around."

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Attaching cancer-killing medicine to fatty acids, researchers say they have found their "Trojan horse" in targeting cancerous tumors in humans, according to a report on the research."It's like a Trojan horse," lead researcher Nathan Gianneschi explained in a statement. "It...
trojanhorse, medicine, drugs, research, study
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2019-19-21
Sunday, 21 July 2019 03:19 PM
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