Tags: Digestive Problems | proton | pump | inhibitors | Nexium | Kidney | stones

Heartburn Meds Like Nexium Linked to Kidney Stones

Heartburn Meds Like Nexium Linked to Kidney Stones

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By    |   Monday, 21 November 2016 01:33 PM

Heartburn sufferers who use a proton pump inhibitors like Nexium may up damage their kidneys and up their risk of stones, new study finds.

Protein pump inhibitors like Nexium, Prilosec, Prevacid, and Zegerid are commonly used to reduce gastric acid production, which can result in heartburn, acid reflux and ulcers.

These medications have been linked to kidney problems, so an Italian research team decided to see whether they increase the risk of kidney stones as well.

They have been found to increase kidney failure in older people, so a new study compared them to drugs known as histamine receptor-2 (H2 blockers), also used for this these conditions.

An Italian research team examined information on 187,330 participants of the Health Professionals Follow-up Study (HPFS) and Nurses’ Health Study (NHS) I and II who were initially free of kidney stones.

During a follow-up of up to 12 years for PPIs and 26 years for H2 blockers, 3245 symptomatic kidney stones developed, the researchers say.

After adjusting for a number of factors such as age, race, body mass index, physical activity, smoking status, comorbidities, use of medications, and intake of nutrients, use of PPIs was associated with a 12 percent higher risk of developing a kidney stone, and use of H2 blockers with a 13 percent higher risk.

In a subgroup of participants, use of PPIs was associated with lower urinary excretion of calcium, oxalate, citrate, and magnesium, which are components of kidney stones, the researchers found.

“Use of PPIs and H2 blockers is associated with a small increase in risk of incident kidney stones. Further studies are needed to confirm our findings and to investigate whether the excess risk is related to a particular type of kidney stones such as those made of calcium oxalate,” says lead author Dr. Pietro Manuel Ferraro.

The research will be presented at ASN Kidney Week 2016, which is underway in Chicago, Ill.


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Certain heartburn meds are linked to kidney problems and a new study finds they may raise kidney stone risk as well.
proton, pump, inhibitors, Nexium, Kidney, stones
Monday, 21 November 2016 01:33 PM
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