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Can One Infection Lead to Alzheimer's?

Monday, 02 Jul 2012 12:21 PM


Chronic inflammation can predispose the brain to develop Alzheimer's disease (AD), and a single infection before birth can set the stage for the devastating disease, says a study published in the Journal of Neuroinflammation.
Swiss and German researchers investigated how challenges to the immune system, similar to having a viral infection, would have on the development of Alzheimer's in mice. They found that a single infection before birth (late in gestation) was enough to induce long-term neurological changes and significant memory problems in old age.
The mice showed a persistent increase in inflammatory cytokines, increased levels of amyloid precursor protein (AAP), and other changes in the brain that are associated with the development of Alzheimer's disease. If the mice had additional severe infections as adults, the effects on the brain were even stronger.
Based on similarities found in both human and mice brains, "it seems likely that chronic inflammation due to infection could be an early event in the development of AD," said research leader Dr Irene Knuesel.
Help may be as close as your medicine cabinet, however, and can be as cheap as a penny a day. Results from the ADAPT (The Alzheimer's Disease Anti-inflammatory Prevention Trial) suggested that taking non-steroidal, anti-inflammatory inflammatory drugs — such as aspirin, ibuprofen, and naproxen — can help people with early stages of the disease.
Other studies back the use of aspirin to give the brain a boost. A study of more than 3,000 people in Utah found that people who took aspirin, Advil, or Ibuprofen four times a week for longer than two years, reduced their risk of developing Alzheimer's by 45 percent.



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Chronic inflammation can predispose the brain to develop Alzheimer's disease (AD), and a single infection before birth can set the stage for the devastating disease, says a study published in the Journal of Neuroinflammation.
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2012-21-02
Monday, 02 Jul 2012 12:21 PM
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