Tags: Cancer | NAC | supplement | breast | cancer | death | risk

Inexpensive Supplement Combats Breast Cancer Death Risk

Image: Inexpensive Supplement Combats Breast Cancer Death Risk
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By    |   Tuesday, 05 Dec 2017 12:13 PM

A safe, inexpensive, over-the-counter supplement can significantly reduce the aggressiveness of breast cancer, says a study published in Seminars in Oncology. Researchers at Philadelphia's The Sidney Kimmel Cancer Center at Thomas Jefferson University found that N-Acetylcystein (NAC) lowered markers of aggressive breast cancer by up to 80 percent.

NAC is a protein that contains L-cysteine, an amino acid used by the body to boost levels of a powerful antioxidant in cells called glutathione which protects the body against free radicals and toxins.

Clinical trials gave patients awaiting surgery for breast cancer maximum daily dosages of NAC for three weeks between diagnosis and surgery. Tumor biopsies were taken before and during surgery, and key biomarkers, including MCT4 and Ki67 were measured.

MCT4 is a protein that sustains and strengthens cancer cells, bringing them energy in the form of lactate from surrounding cells. The study found that NAC inhibited the tumor stroma, a cell compartment which is essential to the spread of cancer, and reduced the ability of cancer cells to feed off of neighboring cells.

After surgery, the patients' Ki67 levels fell by 25 percent, and their MCT4 levels dropped by a whopping 80 percent.

“High levels of stromal MCT4 are extremely worrying, as they are linked to aggressive cancer behavior and poor overall survival, so this is a very encouraging result,” explained Professor Micheal Lisanti of the U.K.'s University of Salford.

"Our idea was to repurpose an inexpensive FDA-approved drug, to examine if its antioxidant properties could target the feeding behavior of cancer cells," said Lisanti. "To be able to inhibit MCT4 protein expression, in a non-toxic way, is a huge step forward.”

Recent studies have found that other common supplements also fight cancer. They include:

Vitamin C. Another study from the University of Salford found that vitamin C was up to 10 times more effective at stopping cancer cells from growing than some pharmaceutical drugs such as 2-DG. The study, which was published in Oncotarget, found that vitamin C (ascorbic acid) killed cancer stem cells, the cells responsible for fueling fatal tumors.

"Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step," said Lisanti.

A recent Japanese study found that vitamin C reduced the risk of dying from breast cancer by 25 percent. Researchers believed vitamin C inhibited glycolysis, which fuels energy production in the cell's "powerhouse" called mitochondria.

Vitamin D-3. A study at the University of California's Moores Cancer Center found that high amounts of vitamin D could cut colorectal cancer rates by two-thirds. Another study, this one published in the British Medical Journal, found that people with the highest levels of vitamin D in their blood lowered their risk of colorectal cancer by almost 40 percent when compared to patients with the lowest levels.

DHA. DHA (docosahexaenoic acid) is found in fish and fish oil pills, and researchers believe it stops cancerous tumors from invading surrounding tissues by inhibiting the creation of new blood vessels.

Researchers at the University of California in San Francisco found that men who ate oily fish such as salmon, herring and mackerel one to three times a month had a 36 percent reduced risk of developing prostate cancer. Those who ate oily fish more than once a week slashed their risk by 57 percent.

Fish oils also eliminated the negative effects of a variant of the COX-2 gene, an inherited gene that encourages inflammation and is linked to a 500 percent increased risk for an aggressive form of prostate cancer.

EGCG. Studies have found that the polyphenol EGCG (epigallocatechin gallate), which is

a powerful anticancer chemical found in green tea, reduces colon cancer in both animals and humans and also enhances the effectiveness of some anti-cancer drugs.

EGCG also impedes the growth of hormone-sensitive cancers, such as breast and prostate cancers, and in addition inhibits leukemia, multiple myeloma, melanoma, and lung cancer.

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A safe, inexpensive, over-the-counter supplement can significantly reduce the aggressiveness of breast cancer, says a study published in Seminars in Oncology. Researchers at Philadelphia's The Sidney Kimmel Cancer Center at Thomas Jefferson University found that...
NAC, supplement, breast, cancer, death, risk
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2017-13-05
Tuesday, 05 Dec 2017 12:13 PM
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