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Metabolic Disease Linked to Liver Cancer

Metabolic Disease Linked to Liver Cancer

(Copyright AP)

By    |   Friday, 14 October 2016 11:24 AM

Two of the risk factors associated with metabolic disease (a combination of health factors such as obesity, high blood pressure, Type 2 diabetes, and high cholesterol) can increase the risk for liver cancer, according to a study published in Cancer Research.


"Liver cancer rates have approximately tripled in the United States since the mid-1970s and the prognosis for patients diagnosed with this type of cancer is especially grim," said Peter Campbell, Ph.D. of the American Cancer Society.


Since obesity rates are increasing in the United States, Campbell and his team studied whether factors that comprise metabolic disease, such as obesity (measured by BMI and waist circumference) and Type 2 diabetes — an obesity related disease — are associated with liver cancer risk.


The researchers used information on 1.7 million U.S. adults from 14 different studies. None of the participants had cancer when they enrolled in the studies, but 6.5 percent had been diagnosed with Type 2 diabetes.


Over time, 2,162 of those who had diabetes developed liver cancer.


The researchers compared the rates of liver cancer among participants with and without obesity and diabetes to determine the relative risks of liver cancer.


When adjusted for alcohol intake, smoking, race, and BMI, participants with Type 2 diabetes were 2.61 times more likely to be diagnosed with liver cancer, and the risk rose with increases in BMI.


The risk rose 8 percent for every 2-inch increase in waist circumference.


"We found that each of these three factors was associated, robustly, with liver cancer risk. All three relate to metabolic dysfunction," Campbell said. "This adds substantial support to liver cancer being on the list of obesity-associated cancers."


Currently, primary liver cancer (hepatocellular carcinoma) is believed to occur in livers damaged by alcohol, birth defects, or from chronic infection from hepatitis B and C. But the new study may add obesity to the main risk factors associated with liver cancer.


"This is yet another reason to maintain a body weight in the 'normal' range for your height," Campbell said.


He noted that the findings are also consistent with other data indicating that obesity and diabetes might be playing a role in the rapid increase in liver cancer in recent decades. "Liver cancer isn't simply related to excess alcohol intake and viral hepatitis infection."
 

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Two of the risk factors associated with metabolic disease (a combination of health factors such as obesity, high blood pressure, Type 2 diabetes, and high cholesterol) can increase the risk for liver cancer, according to a study published in Cancer Research. Liver cancer...
metabolic, disease, link, liver, cancer, obesity, diabetes
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2016-24-14
Friday, 14 October 2016 11:24 AM
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