Tags: gene | tied | lung | cancer | risk | variant | inflammation

Gene Tied to Lower Lung Cancer Risk

Monday, 08 Oct 2012 12:04 PM

A new study backs the theory that inflammation pays a role in the development of lung cancer. Researchers identified a gene variant linked with a decreased risk of lung cancer. The variant occurs in a gene involved with inflammation and immune response. The findings add to growing evidence linking inflammation and immune response with the development of lung cancer, according to the study authors.
They looked at more than 1,400 variants in inflammation- and immunity-related genes from 378 lung cancer patients and 450 healthy people. They found that a variant called "rs4648127" in the NFKB1 gene was associated with a 21 percent to 44 percent reduced risk of lung cancer.
A protein produced in part from the NFKB1 gene is known to play an important role in inflammation and immunity by regulating gene expression, cell death and cell proliferation.
The study was published online Oct. 8 in the journal Cancer.
"Our study provides further evidence that inflammation may be associated with lung cancer risk," study co-author Meredith Shiels, of the U.S. National Cancer Institute, said in a journal news release.
While the study found an association between a gene variant and lung cancer risk, it did not prove a cause-and-effect relationship.
Shiels says that further research is needed to learn more about the link between lung cancer and the NFKB1 gene.

© HealthDay

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A new study that found a gene variant that decreases the risk of lung cancer backs the theory that inflammation pays a role in the development of lung cancer.
Monday, 08 Oct 2012 12:04 PM
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