Tags: Ebola Outbreak | ebola | vaccine | nasal | spray | effective

Nasal Spray Vaccine for Ebola?

By    |   Monday, 03 November 2014 05:14 PM

Researchers at the University of Texas at Austin are reporting promising progress in developing a nasal spray vaccine that has been shown to provide long-term protection for non-human primates against the deadly Ebola virus.

Results from a small pre-clinical study found that a single dose of a non-injectable vaccine for Ebola is long-lasting, which could have significant global implications in controlling future outbreaks. This work is being presented this week at a meeting of the 2014 American Association of Pharmaceutical Scientists in San Diego.
The current Ebola outbreak in West Africa is the largest and most complex epidemic since the virus was first discovered in 1976, according to the World Health Organization.  
Maria Croyle, a professor in the College of Pharmacy at the University of Texas at Austin, Kristina Jonsson-Schmunk, a graduate student in pharmacy, and colleagues at the university developed a nasal formulation that improved survival of immunized non-human primates from 67 percent (two out of three) to 100 percent 150 days after immunization.
"Ebola causes devastating outbreaks with fatality rates of 25-90 percent in Africa and Asia. Although progress has been made in understanding the virus' biology, no licensed vaccines or treatments currently exist. There is a desperate need for a vaccine that not only prevents the continued transmission from person to person, but also aids in controlling future incidences," said Jonsson-Schmunk.
"The main advantage of our vaccine platform over the others in clinical testing is the long-lasting protection after a single intranasal dose. This is important since the longevity of other vaccines for Ebola that are currently being evaluated is not fully understood. Moreover, the nasal spray immunization method is more attractive than a needle vaccine given the costs associated with syringe distribution and safety."
The next stage of the research, which was funded by the National Institutes of Health, will involve clinical trials to test the effectiveness of the vaccine in people.

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Researchers are reporting promising progress in developing a nasal spray vaccine that has been shown to provide long-term protection against the deadly Ebola virus in a study of animals.
ebola, vaccine, nasal, spray, effective
Monday, 03 November 2014 05:14 PM
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