Tags: Diabetes | diabetes | breakthrough | johns | hopkins

Johns Hopkins Diabetes Breakthrough Promises New Treatments

By    |   Wednesday, 06 May 2015 02:51 PM

Johns Hopkins scientists have discovered a cause-and-effect link between chronic high blood sugar and disruption of cellular activities – a finding they say could lead to new ways of preventing and treating diabetes.

The research, reported online in the Proceedings of the National Academy of Sciences, indicates high blood sugar hinders the activity of mitochondria, the powerhouses that create the metabolic energy that runs living cells.

"Sugar itself isn't toxic, so it's been a mystery why high blood sugar can have such a profound effect on the body," noted Gerald Hart, director of the Johns Hopkins University School of Medicine's Department of Biological Chemistry. "The answer seems to be that high blood sugar disrupts the activity of a molecule that is involved in numerous processes within the cell."

Although the research involved mitochondria from the hearts of rats with diabetes, the researchers believe the same mechanisms are at work in people.

Finding a medication that normalizes activity of mitochondria in the face of chronic high blood sugar could be an effective way to prevent or treat diabetes.

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Johns Hopkins scientists have linked chronic high blood sugar to the disruption of cellular activities - a finding they say could lead to new ways of preventing and treating diabetes.
diabetes, breakthrough, johns, hopkins
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2015-51-06
Wednesday, 06 May 2015 02:51 PM
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