Tags: brain plaques | Alzheimer's disease | Alzheimer's clues | memory decline | Alzheimer's genetic risk factors

Early Alzheimer's Brain Changes Revealed

Tuesday, 16 Oct 2012 07:45 AM


Plaques in the brain called beta amyloid may trigger more significant memory loss in healthy older people than the Alzheimer's disease genetic risk factor known as the APOE 4 allele, new research finds.

"Our finding that brain-plaque-related memory decline can occur while people still have normal memory and thinking shows that these plaque-related brain changes can be detected and measured while older people are still healthy," said study author Yen Ying Lim, of the University of Melbourne in Australia. "This provides an enormous opportunity for understanding the development of early Alzheimer's disease and even a sound basis for the assessment of plaque-targeting therapies."

The researchers had nearly 150 older adults with no thinking or memory problems undergo a PET brain scan. The participants, who were an average age of 76, also were tested for the APOE gene.

The group's brain function was monitored for 18 months using computer-based tests, card games, and having the participants memorize word lists.

The study results are published in the Oct. 16 issue of the journal Neurology.

Over the course of the study, the people who began with more brain plaques had up to 20 percent greater decline on the computer-based assessments of memory than the people who had fewer brain plaques.

The researchers also found the participants who carried the APOE gene had greater memory loss than those who did not have this genetic risk factor. They noted, however, that carrying the gene did not affect memory decline associated with the plaques.

"Our results show that plaques may be a more important factor in determining which people are at greater risk for cognitive impairment or other memory diseases such as Alzheimer's disease," Lim said in a journal news release. "Unfortunately, testing for the APOE genotype is easier and much less costly than conducting amyloid imaging."

The research, while demonstrating a link between increased memory loss and plaques, didn't prove causality.





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Measuring brain plaques can offer earlier Alzheimer's clues in older people who are still healthy, new research shows.
brain plaques,Alzheimer's disease,Alzheimer's clues,memory decline,Alzheimer's genetic risk factors
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2012-45-16
Tuesday, 16 Oct 2012 07:45 AM
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