Tags: antibiotic | diuretic | bactrim | death

Beware of Mixing Diuretic With Antibiotic: Researchers

By    |   Tuesday, 03 Feb 2015 04:40 PM

The combination of a commonly prescribed antibiotic with the diuretic spironolactone, widely used for heart failure, more than doubles the risk of death for older patients, researchers say.
 
Urinary tract infections are a common problem for people with congestive heart failure, but researchers found those who took the common antibiotic trimethoprim-sulfamethoxazole (sold under the brand names Septra, Bactrim, and Sulfatrim) while they were on the diuretic spironolactone were more than twice as likely to die, the study found.
 
A Canadian research team conducted the study over 17 years and involved 20,319 patients age 66 or older.
 
"More attention needs to be given to the real risk that trimethoprim-sulfamethoxazole can incite life-threatening hyperkalemia in susceptible individuals and the risks increase when these antibiotics are prescribed with other medications that raise blood potassium, such as spironolactone," said Dr. Tony Antoniou, lead author of the study, which was published in the Canadian Medical Association Journal.
 
Hyperkalemia is the medical term that describes a potassium level in the blood that is higher than normal. The body needs potassium, but too much can lead to dangerous and potentially deadly heartbeat irregularities.
 
 

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The combination of a commonly prescribed antibiotic with the diuretic spironolactone, widely used for heart failure, more than doubles the risk of death for older patients, researchers say. Urinary tract infections are a common problem for people with congestive heart...
antibiotic, diuretic, bactrim, death
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2015-40-03
Tuesday, 03 Feb 2015 04:40 PM
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