Dr. Chauncey W. Crandall, author of Dr. Crandall’s Heart Health Report newsletter, is chief of the Cardiac Transplant Program at the world-renowned Palm Beach Cardiovascular Clinic in Palm Beach Gardens, Fla. He practices interventional, vascular, and transplant cardiology. Dr. Crandall received his post-graduate training at Yale University School of Medicine, where he also completed three years of research in the Cardiovascular Surgery Division. Dr. Crandall regularly lectures nationally and internationally on preventive cardiology, cardiology healthcare of the elderly, healing, interventional cardiology, and heart transplants. Known as the “Christian physician,” Dr. Crandall has been heralded for his values and message of hope to all his heart patients.

Tags: cardiac drugs | carotid artery | lipids

Personalized Drugs Target Heart Disease

By
Friday, 20 April 2018 04:37 PM Current | Bio | Archive

A drug that cut the rate of heart attacks and deaths in patients with a certain genetic makeup could pave the way for a new era of personalized medications for the treatment of heart disease.

Scientists from the Montreal Heart Institute gave either the medication dalcetrapib or a placebo to 5,749 patients. Dalcetrapib is a CETP inhibitor, which is a drug that is intended to reduce the risk of heart disease by improving blood lipid levels.

In the study, researchers found that patients with a variant for a gene called ADCY9 experienced a 39 percent reduction in cardiovascular events such as heart attacks, strokes, unstable angina, or cardiac death when they were given the drug.

Supporting evidence was also obtained from a second study, which showed that patients with the favorable genetic profile also benefited from a reduction in the thickness of their carotid artery walls with dalcetrapib.

The carotid arteries are the vessels in the neck that carry blood from the heart to the brain, and their clogging increases stroke risk.

Targeted drugs are increasingly used to treat cancer, and research like this could usher in a new generation of more effective cardiac drugs.

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Dr-Crandall
A drug that cut the rate of heart attacks and deaths in patients with a certain genetic makeup could pave the way for a new era of personalized medications for the treatment of heart disease.
cardiac drugs, carotid artery, lipids
195
2018-37-20
Friday, 20 April 2018 04:37 PM
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