All acid-blocking medications are associated with serious side effects, including disruption of normal gastrointestinal flora.
But in the case of proton pump inhibitors (PPIs), the adverse effects are even more severe than H2 blockers.
PPIs have only been approved for short-term use. A recent study found that long-term use of PPIs is associated with a 45 percent increase in risk of chronic kidney disease.
When PPI users were compared with users of H2 blockers, there was a 39 percent increase risk of kidney disease. Twice daily dosing of a PPI was associated with a 200 percent increase in the risk of kidney disease.
PPIs are also associated with pernicious anemia or severe vitamin B12 deficiency, because B12 needs an acidic stomach for proper absorption.
Other ailments associated with low stomach acid production include:
• Acne and rosacea
• Autoimmune disorders (Hashimoto’s and Graves’ diseases, lupus, rheumatoid arthritis)
• Gallbladder infection and stones
• Kidney failure
• Leaky gut
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