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Tags: resveratrol | grapes | brain | Alzheimers

Magic Extract for Mind and Body

By Wednesday, 22 January 2014 04:22 PM Current | Bio | Archive

The extract resveratrol, which is found in the skin of red grapes, has gotten a lot of attention because it has been shown to extend the lifespan of animals. It has anticancer properties, and a powerful ability to protect the brain against immunoexcitotoxicity, the central mechanism in brain aging and neurodegenerative disease of the brain. It is a potent antioxidant that stimulates brain growth and synaptic connections.
Resveratol can also mimic the effects of fasting. In fact, it appears to confer all the beneficial effects of actual fasting and dietary caloric restriction without having to go through extreme dietary changes.
Editor's Note: The Benefits of Resveratrol and Probiotics: Fact or Fiction?

In the past, it was thought that resveratrol’s benefits were the result of stimulating a cell-signaling substance called sirtuins (SIRT1). But a new study found that it prolongs life by stimulating AMPK.
One of the really interesting properties of AMPK stimulation is that it causes mitochondria to reproduce within cells, especially neurons. By making more mitochondria per cell, the neuron has more energy without the added risk of producing a lot of free radicals. (Mitochondria are, after all, the major source of free radicals.)

Resveratrol also causes robust outgrowth of neurites — that is, brain connections — and is a major weapon against immunoexcitotoxicity. Because of its effect on neuronal AMPK, resveratrol reduces the damage caused by strokes, brain oxidative stress, immunoexcitotoxicity, and post-traumatic seizures. Animal models have shown that it also protects against Alzheimer’s and Huntington’s disease.

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The extract resveratrol, which is found in the skin of red grapes, has gotten a lot of attention because it has been shown to extend the lifespan of animals.
Wednesday, 22 January 2014 04:22 PM
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