Tags: Obesity | fatty | liver | drug | treatment

Drug Offers Hope Against Fatty Liver Disease

By    |   Wednesday, 18 February 2015 01:28 PM

Researchers are developing a drug that halts non-alcoholic fatty liver disease, stopping it from progressing to a more serious condition that can result in liver damage and death.
 
Up to 30 percent of the U.S. population may have abnormal fat accumulation in the liver, known as non-alcoholic fatty liver disease (NAFLD), and the rate is climbing, fueled by obesity.
 
In some people, NAFLD can be a fairly benign condition that doesn't affect their daily lives. However, others develop liver inflammation and scarring that results in a more serious disease known as nonalcoholic steatohepatitis (NASH).
 
Currently there are no approved treatments for NASH, but a research team at Saint Louis University Medical Center is testing a promising new drug called SR9238 which suppresses lipogenesis, the fat accumulation process in the liver.
 
“The drug is liver specific, so it gets to the liver, stays there and reduces the liver's ability to produce fat,” said Thomas Burris, Ph.D., who led the team that is developing the drug.
 
They have tested the drug in mice that were fed a special high transfat, high-fructose diet to induce fatty liver disease. The drug stopped disease progression, and halted liver scarring, Burris said.
 
The drug now must be tested in clinical trials to make sure that it is safe and effective in humans, the researchers said.
 
 

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Researchers are developing a drug that halts non-alcoholic fatty liver disease, stopping it from progressing to a more serious condition that can result in liver damage and death. Up to 30 percent of the U.S. population may have abnormal fat accumulation in the liver,...
fatty, liver, drug, treatment
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2015-28-18
Wednesday, 18 February 2015 01:28 PM
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