Tags: Obesity | drug | GC-1 | metabolism | fat | brown | obesity

New Drug Turns Unhealthy White Fat Into Calorie-Burning Brown Fat

Monday, 09 March 2015 12:44 PM


A newly discovered drug tested on mice reportedly speeds up metabolism by turning the body's energy-storing, "bad" white fat into energy-burning "good" brown fat.
 
Discovered by researchers in the US state of Texas, the drug is called GC-1 and it could become important in the fight against obesity.
 
"GC-1 dramatically increases the metabolic rate, essentially converting white fat, which stores excess calories and is associated with obesity and metabolic disease, into a fat like calorie-burning brown fat," says study author Kevin Phillips, PhD of the Houston Methodist Research Institute.
 
Several recent studies have shown that the two types of fat can convert into each other, and Dr. Phillips says that brown fat could convert to white with age, losing its calorie-burning capabilities.
 
The new drug activates receptors for thyroid hormone, which regulates the process of converting food into energy, called metabolism.
 
Excess calories and fat convert to heat in a process called thermogenesis, however, this process only occurs in brown fat and is controlled by thyroid hormone receptors, according to the study.
 
Dr. Phillips and his team tested GC-1 in hundreds of mice that had either genetic obesity or diet-induced obesity.
 
After daily treatment with GC-1, even the mice that were genetically obese managed to lose weight and more than 50 percent of their fat mass in roughly two weeks.
 
The mice's insulin sensitivity -- which refers to how well the body can flush glucose from the bloodstream -- was significantly improved in both genetically obese mice and those who had diet-induced obesity.
 
Working with samples of the mice's fat tissue that had been removed, and with fat cells cultured in a petri dish, the research team observed that the cells were turning from white to brown.
 
While the drug has yet to be tested for weight loss in humans, clinical trials are underway for lowering cholesterol, using much lower doses than what would be necessary for weight loss.
 
Dr. Philips and his team presented their findings on Friday at ENDO 2015, the Endocrine Society's 97th annual meeting in San Diego.
 

© AFP/Relaxnews 2020


   
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A newly discovered drug tested on mice reportedly speeds up metabolism by turning the body's energy-storing, bad white fat into energy-burning good brown fat. Discovered by researchers in the US state of Texas, the drug is called GC-1 and it could become important in...
drug, GC-1, metabolism, fat, brown, obesity
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2015-44-09
Monday, 09 March 2015 12:44 PM
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