Tags: diabetes drug | alzheimers | breakthrough | triple receptor

Diabetes Drug an Alzheimer's Breakthrough? Triple Receptor Shows Promise

(Sandor Kacso/Dreamstime.com)

By    |   Thursday, 04 January 2018 11:54 AM

A diabetes drug could be an Alzheimer's breakthrough, according to researchers who found that the medicine significantly reversed memory loss and brain deterioration in mice.

In a report posted this week in the science journal Brain Research, researchers at England's Lancaster University said their work suggested that rodents suffering from a version of Alzheimer's disease improved greatly with the drug, Newsweek magazine reported.

The drug, known as a triple receptor and which combines the growth factors GLP-1, GIP and Glucagon, was reported to have improved the memory of aged mice in maze tests after taking the drug. The mice also had a reduced buildup of plaque in the brain, chronic inflammation, and brain nerve cell loss while gaining brain nerve cell protection, Newsweek reported from the research.

"With no new treatments in nearly 15 years, we need to find new ways of tackling Alzheimer's," Doug Brown, director of research and development at the Alzheimer's Society, said in a statement from Lancaster University. "It's imperative that we explore whether drugs developed to treat other conditions can benefit people with Alzheimer's and other forms of dementia. This approach to research could make it much quicker to get promising new drugs to the people who need them."

Brown said other studies with existing diabetes drugs such as liraglutide also have shown promise for people with Alzheimer's, and he encouraged continued research on the links.

"These very promising outcomes demonstrate the efficacy of these novel multiple receptor drugs that originally were developed to treat Type 2 diabetes but have shown consistent neuro- protective effects in several studies," said Christian Holscher, the study's lead researcher and Lancaster professor.

"Clinical studies with an older version of this drug type already showed very promising results in people with Alzheimer's disease or with mood disorders. Here we show that a novel triple receptor drug shows promise as a potential treatment for Alzheimer's but further dose-response tests and direct comparisons with other drugs have to be conducted in order to evaluate if this new drugs is superior to previous ones."

Such drugs could have a dramatic impact in the coming years. According to the Fisher Center for Alzheimer's Research Foundation, studies have shown that the number of men and women with Alzheimer's disease are expected to triple in the next 40 years, increasing to 13.8 million from the 4.7 million in 2010.

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A diabetes drug could be an Alzheimer's breakthrough, according to researchers who found that the medicine significantly reversed memory loss and brain deterioration in mice.
diabetes drug, alzheimers, breakthrough, triple receptor
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2018-54-04
Thursday, 04 January 2018 11:54 AM
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