Tags: Cancer | ovary | removal | breast | cancer | angelina | jolie

Ovary Removal Found to Cut Breast Cancer Risk

By    |   Thursday, 23 April 2015 02:07 PM

Removal of the ovaries — a procedure known as an oophorectomy — not only eliminates the risk of develop ovarian cancer, but also produces a marked drop in breast cancer risk, new research shows.

The procedure, undergone by Angelina Jolie to reduce her cancer risk, was associated with a 62 percent reduction in death in women diagnosed with breast cancer and carrying a BRCA1 gene mutation linked to the disease, according to the study published online by JAMA Oncology.

Women who carry a mutation in either the BRCA1 or BRCA2 gene face a lifetime risk of breast cancer of up to 70 percent, experts note. Once they are diagnosed with breast cancer, they face high risks of both second primary breast and ovarian cancers.

To reach their conclusions, lead researchers — Steven A. Narod, M.D., and Kelly Metcalfe, of the Women's College Research Institute, Toronto — tracked 676 women, about half of whom underwent oophorectomy after being diagnosed with breast cancer, while the others retained both ovaries.

The study found 20-year survival for both groups of women was 77.4 percent. But women who had their ovaries removed had a 56 percent reduction in breast cancer death — while those with a BRCA1 mutation had an even greater risk reduction: 62 percent.

"It is important that follow-up studies be performed on women who undergo oophorectomy as part of their initial treatment, in particular, those women who undergo oophorectomy in the first year after diagnosis. It is also important that our observations be confirmed in other study populations. Further data are needed, in particular for BRCA2 carriers in order to confirm the benefit of oophorectomy in this population," the researchers concluded.

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Removal of the ovaries not only eliminates the risk of develop ovarian cancer, but also produces a marked drop in breast cancer risk, scientists say.
ovary, removal, breast, cancer, angelina, jolie
Thursday, 23 April 2015 02:07 PM
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