Tags: Cancer | liquid | biopsies | tissue | lung | cancer

Liquid Biopsies May Beat Tissue Biopsies for Treating Advanced Lung Cancer

Liquid Biopsies May Beat Tissue Biopsies for Treating Advanced Lung Cancer

(Copyright iStock)

By    |   Monday, 12 September 2016 12:22 PM


A non-invasive liquid biopsy may be more effective than a standard tissue biopsy to give doctors the direction they need to determine treatment, says a study published in the journal Clinical Cancer Research.


In patients with advanced non-small cell lung cancer (NSCLC) being treated at the Abramson Cancer Center at the University of Pennsylvania (ACC), mutations detected from liquid biopsies (cell-free circulating tumor DNA [ctDNA] captured from blood) closely paralleled the mutations from tissue biopsies identified in advanced gene sequencing tests.


In addition, liquid biopsies discovered clinically relevant mutations that weren't found in tissue biopsies as the patients' disease progressed.


"This represents a bit of a paradigm shift," said senior author Erica L. Carpenter, Ph.D. of the Perelman School of Medicine at the University of Pennsylvania. "The tissue biopsy sequencing result has been considered the gold standard against which one compares the ctDNA result."


The study suggests that doctors can get reliable results from liquid biopsies and use them to determine effective changes in treatment. "It also offers the advantage of testing without discomfort to the patient and possible risks associated with invasive biopsies," says Carpenter.


In the study, researchers enrolled 102 consecutive patients with advanced NSCLC who had blood samples sent for ctDNA testing as part of their routine clinical care. Most were women (68 percent) with adenocarcinoma (81 percent) and stage IV disease (96 percent), all with different courses of treatment.


Liquid biopsy samples were collected in all 102 patients and sent to Guardant Health in California for genomic analysis. Tissue samples were only able to be collected in 50 patients and subsequently analyzed at Penn's Center for Personalized Diagnostics with a 47-gene panel.


Among blood and tissue samples that were obtained at the same time, agreement between the two tests was nearly 100 percent.


"The ever-expanding number of targeted therapies for lung cancer patients has been accompanied by a need for diagnostics with real-time detection of therapeutically targetable mutations," said co-author Corey J. Langer, M.D., a professor of Hematology/Oncology and director of the Thoracic Oncology Program in Penn's Abramson Cancer Center, and a treating physician on the trial.


"More and more, liquid biopsies are proving to help fill this need," Corey said. "While tissue samples will likely remain a major part of the initial diagnostic process, this non-invasive approach appears to be another powerful tool in our toolbox to help determine the best course of treatment for lung cancer patients."

Non-small cell lung cancer accounts for about 85 percent of the more than 200,000 cases of lung cancer diagnosed every year in the United States. Adenocarcinoma, squamous cell carcinoma, and large cell carcinoma are all subtypes of NSCLC.


According to the American Cancer Society, 5-year survival for stage III NSCLC is between 5 and 14 percent, while the rate for patients with stage IV NSCLC is only about 1 percent.

 

© 2021 NewsmaxHealth. All rights reserved.


   
1Like our page
2Share
Health-News
A non-invasive liquid biopsy may be more effective than a standard tissue biopsy to give doctors the direction they need to determine treatment, says a study published in the journal Clinical Cancer Research. In patients with advanced non-small cell lung cancer (NSCLC)...
liquid, biopsies, tissue, lung, cancer
473
2016-22-12
Monday, 12 September 2016 12:22 PM
Newsmax Media, Inc.
 
Newsmax TV Live

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

NEWSMAX.COM
© Newsmax Media, Inc.
All Rights Reserved