Tags: Health Topics | Cancer | kidney cancer | treatment | cabozantinib

Study: Drug Improves Survival for Kidney Cancer

kidney cancer
Light micrograph of kidney cancer (Dreamstime)

Monday, 22 February 2021 09:28 AM

The drug cabozantinib is more effective than two similar drugs, as well as the current standard treatment, in extending the lives of patients with a rare and deadly type of kidney cancer, according to a new study.

The cancer is called metastatic papillary kidney cancer. There are currently no effective treatments for it. A previous study of 38 patients found that the average survival rate was just eight months after diagnosis.

These findings could change how the cancer is treated, the research suggested.

"We still have a long way to go to help make patients' lives longer and better, but we do have a new standard treatment for these rare cancer patients," said study author Dr. Sumanta Pal, a clinical professor of medical oncology at City of Hope Cancer Center in Duarte, Calif. She's also a researcher in the SWOG Cancer Research Network.

Mutations in the MET gene are a hallmark of this type of this kidney cancer, and new drugs target the MET gene, along with other important signaling pathways.

In this study of 147 patients, researchers compared three MET target drugs — cabozantinib, crizotinib, and savolitinib — with the current standard treatment, sunitinib, a receptor tyrosine inhibitor.

The patients, most of whom hadn't received any prior treatment, were randomly assigned to receive one of the four treatments.

Progression-free survival (the time it took before the cancer returned or spread) was a median of 5.6 months in the sunitinib group, and much shorter in the savolitinib and crizotinib groups.

However, it was 9.2 months in the cabozantinib group, and 23% of those patients had a significant reduction in the size of their tumor, versus 4% of those in the sunitinib group, the SWOG Cancer Research Network study found.

"The magnitude of the response was surprising," Pal added in a SWOG/City of Hope news release. 

The study was presented earlier this month at a virtual American Society of Clinical Oncology meeting and published simultaneously in The Lancet journal.

SWOG Cancer Research Network is part of the U.S. National Cancer Institute's National Clinical Trials Network. City of Hope is an NCI-designated comprehensive cancer care center.

© HealthDay


Health-News
The drug cabozantinib is more effective than two similar drugs, as well as the current standard treatment, in extending the lives of patients with a rare and deadly type of kidney cancer, according to a new study...
kidney cancer, treatment, cabozantinib
352
2021-28-22
Monday, 22 February 2021 09:28 AM
Newsmax Media, Inc.
 
Newsmax TV Live
 

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

NEWSMAX.COM
© Newsmax Media, Inc.
All Rights Reserved