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Erectile Dysfunction Drugs Don't Prevent Prostate Cancer

Erectile Dysfunction Drugs Don't Prevent Prostate Cancer

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Tuesday, 02 August 2016 11:57 AM

Erectile dysfunction (ED) drugs don't prevent prostate cancer, according to a new study from Cedars-Sinai in Los Angeles. Although some previous research indicated that taking ED drugs lowered the risk, the four-year study found no such link.


ED is a common problem in older men. In those older than 50, 20 percent to 40 percent suffer from the problem, and the incidence nears 75 percent in the seventh decade.


Drugs such as Viagra (sildenafil), Cialis (tadalafil), and Levitra (vardenafil) are phosphodiesterase type 5 inhibitors (PDE-5is) that are commonly used to treat ED.


ED drugs were introduced in 1998, and they have been found to be safe and effective. Some studies have even indicated they may protect men from developing prostate cancer.


"In vitro mouse studies have suggested that these drugs might have some anticancer activity, but the evidence in human subjects is mixed," said lead investigator Stephen J. Freedland, M.D., Division of Urology, Department of Surgery at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai in Los Angeles, CA.


"Given the routine use of PDE-5i and the possibility that these agents may have anticancer activity, we wanted to test the association between their use and risk of developing prostate cancer," he said.


At the beginning of the study, 364 (5.6 percent) of the 6,501 men used PDE-5i. During the study, prostate cancer was diagnosed in 71 of these men (19.5 percent) compared to 1,391 of 6,137 (22.7 percent) men who did not take PDE-5i. The researchers didn't consider the difference significant. They also found that ED use didn't affect the severity of the cancer in those who were diagnosed with the disease.


Still, the researchers believe more research needs to be done. "Future studies with longer follow-up and larger study populations are warranted to determine the association between PDE-5i and prostate cancer," said the study's first author Juzar Jamnagerwalla, M.D.

 

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Erectile dysfunction (ED) drugs don't prevent prostate cancer, according to a new study from Cedars-Sinai in Los Angeles. Although some previous research indicated that taking ED drugs lowered the risk, the four-year study found no such link. ED is a common problem in older...
erectile, dysfunction, drugs, ED, prostate, cancer
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2016-57-02
Tuesday, 02 August 2016 11:57 AM
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