Tags: Cancer | drug-resistant | lung | cancer | killed | chemo

Drug-Resistant Lung Cancer Killed With 50 Times Less Chemo

Drug-Resistant Lung Cancer Killed With 50 Times Less Chemo
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Thursday, 14 January 2016 01:24 PM


Researchers at the University of North Carolina at Chapel Hill have developed a new way to package cancer drugs in immune bubbles made from a patient's own immune system and deliver them directly to tumors. The result? Less chemo and better results.

The scientists used a drug called paclitaxel that is used to treat breast, lung and pancreatic cancers. However, it can have serious side effects, such as hair loss, muscle and joint pain and diarrhea, and it increases the risk of infection.

The new technique keeps the drug from being destroyed by the body's immune system, and delivers the entire payload directly to the tumor.

"That means we can use 50 times less of the drug and still get the same results," said Elena Batrakova, Ph.D., an associate professor in the UNC Eshelman School of Pharmacy. "That matters because we may eventually be able to treat patients with smaller and more accurate doses of powerful chemotherapy drugs resulting in more effective treatment with fewer and milder side effects."

The technique is based on exosomes, which are tiny spheres harvested from the white blood cells that protect the body against infection. The exosomes are made of the same material as cell membranes, and the patient's body doesn't recognize them as foreign, which has been one of the toughest issues to overcome in the past decade with using plastics-based nanoparticles as drug-delivery systems.

"Exosomes are engineered by nature to be the perfect delivery vehicles," said Batrakova, who has also used this technique as a potential therapy for Parkinson's disease. "By using exosomes from white blood cells, we wrap the medicine in an invisibility cloak that hides it from the immune system.

"We don't know exactly how they do it, but the exosomes swarm the cancer cells, completely bypassing any drug resistance they may have and delivering their payload," says Batrakova.

In their experiment, Batrakova's team extracted exosomes from mouse white blood cells and loaded them with paclitaxel. They then tested the treatment -- which they call exoPXT -- against multiple-drug-resistant cancer cells in petri dishes. The team saw that they needed 50 times less exoPXT to achieve the same cancer-killing effect as formulations of the drug currently being used, such as Taxol.

The researchers next tested the therapy in mouse models of drug-resistant lung cancer. They loaded the exosomes with a dye in order to track their progress through the lungs and found that the exosomes were thorough in seeking out and marking cancer cells, making them a surprisingly effective diagnostic tool in addition to being a powerful therapeutic.

"Accurately mapping the extent of tumors in the lungs is one of the biggest challenges in treating lung-cancer patients," said Batrakova. "Our results show how powerful exosomes can be as both a therapeutic and a diagnostic."

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Researchers at the University of North Carolina at Chapel Hill have developed a new way to package cancer drugs in immune bubbles made from a patient's own immune system and deliver them directly to tumors. The result? Less chemo and better results. The scientists used a...
drug-resistant, lung, cancer, killed, chemo
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2016-24-14
Thursday, 14 January 2016 01:24 PM
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