Tags: Cancer | chemo | resistant | cancer | advance

Scientists Discover Way Fight Chemo-Resistant Cancers

By    |   Thursday, 24 April 2014 04:18 PM

British scientists have identified a way to make cancer cells that have become resistant to chemotherapy more vulnerable to the drugs, making them more open to treatment.
 
The findings, by University of Manchester researchers, could open the door to the development of new medicines to treat drug-resistant tumors, Medical Xpress reports.
 
Lead researcher Andrew Gilmore, M.D., who detailed the work in the journal Cell Reports, explained that tumor cells divide and multiply rapidly — through process known as mitosis — and chemo drugs such as Paclitaxel target those quickly replicating cells. But tumors can develop resistance to those drugs, rendering them ineffective.
 
But Dr. Gilmore's team identified a particular protein known as "bid" in colon cancer cells that, when switched on, causes the tumors to die if cell division takes too long. Cancer cells that are resistant to chemotherapy go through mitosis too quickly for the protein to kill the cell. But the researchers found those resistant cells could be made to die by directly targeting the part of the cell where the protein works.
 
"Our findings demonstrate that 'bid' plays a central role in mitosis-related cell death," Dr. Gilmore said. "This opens up new areas of research into drugs that might be able to kill cancer cells that have become resistant to chemotherapy. This could eventually be of huge benefit in a clinical setting and help patients who suffer from advanced stages of colon cancer."

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A new way has been identified by British scientists to make cancer cells that have become resistant to chemotherapy more vulnerable to the drugs, making them more open to treatment.
chemo, resistant, cancer, advance
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2014-18-24
Thursday, 24 April 2014 04:18 PM
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