Tags: Cancer | cancer | test | blood

Universal Cancer Test Discovered

By    |   Monday, 28 July 2014 02:55 PM

British researchers from the University of Bradford have devised a simple blood test that they say can be used to diagnose cancer.

The test could enable doctors to rule out cancer in patients with certain symptoms simply, bypassing costly, time-consuming, and unnecessary invasive procedures such as colonoscopies and biopsies.
 
Such a test could also help identify patients who are suspected of having a cancer that is currently hard to diagnose.
 
Editor’s Note: 5 Signs Cancer Is Starting Inside Your Body

Preliminary results — detailed in the FASEB Journal, published by the Federation of American Societies for Experimental Biology — indicate the test has a high degree of accuracy in diagnosing cancerous and pre-cancerous conditions from the blood of patients with melanoma, colon cancer, and lung cancer.  
 
The so-called LGS test — short for Lymphocyte Genome Sensitivity — examines white blood cells and measures the damage caused to their DNA when subjected to different intensities of ultraviolet light (UVA), which is known to damage DNA. The results of the study show a clear distinction between the damage to the white blood cells from patients with cancer, with pre-cancerous conditions, and from healthy patients.
 
 “White blood cells are part of the body’s natural defense system. We know that they are under stress when they are fighting cancer or other diseases, so I wondered whether anything measureable could be seen if we put them under further stress with UVA light,” said lead researcher Diana Anderson, from the University’s School of Life Sciences.
 
“We found that people with cancer have DNA which is more easily damaged by ultraviolet light than other people, so the test shows the sensitivity to damage of all the DNA – the genome – in a cell.”
 
The study examined blood samples taken from 208 individuals. Ninety-four healthy individuals were recruited from staff and students at the University of Bradford and 114 blood samples were collected from patients referred to specialist clinics within Bradford Royal Infirmary prior to diagnosis and treatment.
 
“These are early results completed on three different types of cancer and we accept that more research needs to be done; but these results so far are remarkable,” said Anderson. "Whilst the numbers of people we tested are, in epidemiological terms, quite small, in molecular epidemiological terms, the results are powerful. We’ve identified significant differences between the healthy volunteers, suspected cancer patients and confirmed cancer patients of mixed ages at a statistically significant level … This means that the possibility of these results happening by chance is 1 in 1000. We believe that this confirms the test’s potential as a diagnostic tool.”
 
The University of Bradford has filed patents for the technology and a spin-of company, Oncascan, has been established to commercialize the research.
 
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British researchers have devised a simple blood test that they say can be used to diagnose cancer. The test could enable doctors to rule out cancer in patients with certain symptoms simply, bypassing costly, time-consuming, and invasive diagnostic techniques.
cancer, test, blood
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2014-55-28
Monday, 28 July 2014 02:55 PM
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