Tags: Allergies | Cancer | allergy | inflammation | cancer

Allergies Raise Cancer Risk: Study

By    |   Thursday, 30 April 2015 01:06 PM

Troubling new research suggests allergic reactions — and/or inflammation they cause — may promote the spread of cancer from one area of the body to another.

The findings, published in the Journal of Leukocyte Biology, are based on studies of mice that showed inflammation raises the level of a known biomarker of cancer —called "chitinase-3-like-1" or "CHI3L1," — in inflamed tissues, which boosts the growth and spread (metastasis) of tumors.

"The research we have done is striking in that we showed pre-existing inflammation may be one of the factors that accelerates metastasis to the inflamed site," said lead researcher Vijaya L. Iragavarapu-Charyulu, with the Charles E. Schmidt College of Medicine at Florida Atlantic University.

"We hope that this study is a fundamental building block for future studies on how other inflammatory diseases may predispose patients for increased metastasis."

The findings may help explain why anti-inflammatory drugs, treatments, and natural remedies may help combat cancer and other conditions.

To reach their conclusions, the researchers studied two groups of mice, one of which was genetically modified so it could not produce the CHI3L1 glycoprotein, and engineered to develop cancer.

After four weeks, the mice lacking CHI3L1 had slower-growing tumors that did not spread as rapidly as the others.

"There is increasing evidence of a link between inflammation and cancer," noted John Wherry, deputy editor of the Journal of Leukocyte Biology. "While normally inflammation helps us fight of infections, chronic inflammation has been linked to increased risk of tumor development.

“These new studies begin to shed light on an important way this link between inflammation and malignancy may work, providing a potential starting point for developing inflammation-based therapeutics to treat cancer."

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Allergic reactions - and/or inflammation they cause - may promote the spread of cancer from one area of the body to another, new research suggests.
allergy, inflammation, cancer
Thursday, 30 April 2015 01:06 PM
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