Tags: telomeres | reverse | aging

Scientists Lengthen Human Telomeres to Reverse Aging

By    |   Friday, 23 January 2015 03:36 PM

Stanford medical researchers have devised a new procedure that can efficiently increase the length of protective caps on the ends of chromosomes that are linked to aging and disease.

The treated caps — called telomeres —behave as if they are much younger than untreated cells, multiplying with abandon in the laboratory dish rather than stagnating or dying, according to scientists at the Stanford University School of Medicine.
 
The procedure involves the use of a modified type of RNA and improves the ability of researchers to generate large numbers of cells for study or drug development, Medical Express reports. 
 
For example, skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells. The research may point to new ways to treat diseases caused by shortened telomeres.
 
Telomeres are the protective caps on the ends of the strands of DNA called chromosomes, which house our genomes. In young people, telomeres are about 8,000-10,000 nucleotides long, but they shorten with each cell division as we age. When they reach a critical length the cell stops dividing or dies.
 
"Now we have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life," said Helen Blau, professor of microbiology and immunology at Stanford and director of the university's Baxter Laboratory for Stem Cell Biology. "This greatly increases the number of cells available for studies such as drug testing or disease modeling."
 
The new work was published in the FASEB Journal.

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Anti-Aging
Stanford researchers have devised a new procedure that can efficiently increase the length of protective caps on the ends of chromosomes that are linked to aging and disease.
telomeres, reverse, aging
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2015-36-23
Friday, 23 January 2015 03:36 PM
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