Tags: Menopause | menopause | brain | fog | adhd | medicine | drugs

Menopause 'Brain Fog' Helped by ADHD Drug: Study

By    |   Thursday, 11 June 2015 02:22 PM

Women who experience problems with memory, attention, and problem solving appear to benefit from a drug used to treat attention deficit hyperactivity disorder.

University of Pennsylvania researchers report that lisdexamfetamine (LDX) led to marked improvements in several  measures of cognitive decline commonly experienced in menopausal women — sometimes referred to as “brain fog.”

The findings, published online in the journal Psychopharmacology, suggest LDX may help tens of millions of millions of women cope with the psychological aspects brought on by the change of life.

"Reports of cognitive decline, particularly in executive functions, are widespread among menopausal women," said lead researcher C. Neill Epperson, M.D., professor of psychiatry, obstetrics, and gynecology at the Perelman School of Medicine at the University of Pennsylvania.

"There are approximately 90 million post-menopausal women living in the US alone, and with the average age of onset occurring at 52, the great majority of those women will live in the postmenopausal state for at least one-third of their lives. Therefore, promoting healthy cognitive aging among menopausal women should be a major public health goal."

For the study, the researchers administered a once-daily dose of LDX for four weeks to 32 healthy, non-ADHD-diagnosed women between the ages of 45 and 60 experiencing difficulties with executive functions as a result of mid-life onset menopause.

The researchers found a 41 percent overall improvement in executive functions for women receiving LDX, compared to a 17 percent improvement when taking a placebo medication. There were also significant improvements the women’s organizational skills, motivation for work, attention and concentration, alertness, and working memory.

"Although we observed that short-term use of LDX was well tolerated and effective in several subjective and objective areas, long-term studies of menopausal women receiving LDX are needed, similar to those conducted for ADHD patients," said Dr. Epperson.

"It is also important for clinicians to confirm that a woman's complaints of worsening memory are in the executive function domains, are temporally related to the transition to menopause, and are not indicative of some other pathological cognitive impairment before prescribing a trial of LDX."

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Post-menopausal women who experience problems with memory, attention, and problem solving appear to benefit from a drug used to treat attention deficit hyperactivity disorder.
menopause, brain, fog, adhd, medicine, drugs, attention, deficit
Thursday, 11 June 2015 02:22 PM
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