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Study Questions Benefits of Testosterone for Low T

Study Questions Benefits of Testosterone for Low T

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By    |   Thursday, 22 September 2016 11:52 AM

Millions of American men with low testosterone take testosterone supplements to improve their sexual function, cardiovascular health, mood, or cognitive function. But a review of more than 200 clinical trials found that the practice isn't supported by clinical data.


"Testosterone has been marketed to improve a number of conditions, but for the vast majority our review of the data shows that not one of these claims has adequate clinical trial support," says Dr. Adriane Fugh-Berman from Georgetown University Medical Center.


Fugh-Berman and her colleagues analyzed randomized, placebo-controlled trials that compared testosterone to placebo for cardiovascular health, sexual function, physical function, mood, or cognitive function.


They found that testosterone supplements failed to show improvements on many levels. The research, which was published in PLOS ONE, found:


• Testosterone supplements "did not show consistent benefit for cardiovascular risk, sexual function, mood and behavior, or cognition."


• Improvement is seen in some surrogate markers of cardiovascular risk, but there is "little evidence" of clinical benefit.


• Studies that examined clinical cardiovascular endpoints "have not favored testosterone therapy over placebo."


• Testosterone is "ineffective" in treating erectile dysfunction and "did not show a consistent effect on libido."


• Testosterone supplementation consistently increased muscle strength but "did not have beneficial effects on physical function."


• "Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality, psychological well-being, or mood."


"Testosterone products are marketed for non-specific symptoms associated with normal aging, but testosterone is not a reasonable treatment for aging," says Fugh-Berman.

"Testosterone has known risks and no clear benefits, and shouldn't be used by men with intact testicles."


According to a recent study, researchers from NYU Langone Medical Center found that the use of testosterone therapy to treat "low T" has skyrocketed among baby boomers, tripling since 2001.


Some surveys show that 2 percent of American men in their 40s and almost 4 percent in their 60s take testosterone replacement, either by mouth, gel patch or injection.


Questions have lingered about whether or not testosterone replacement therapy to boost lagging levels of the sex hormone were increasing the risk of prostate cancer, but a study of 250,000 Swedish men found that not only did testosterone supplements not increase the rate of prostate cancer, it was reduced by 50 percent.
 

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Millions of American men with low testosterone take testosterone supplements to improve their sexual function, cardiovascular health, mood, or cognitive function. But a review of more than 200 clinical trials found that the practice isn't supported by clinical data. ...
benefits, testosterone, questioned, Low T
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2016-52-22
Thursday, 22 September 2016 11:52 AM
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