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Chauncey W. Crandall, M.D., F.A.C.C.

Dr. Chauncey W. Crandall, author of Dr. Crandall’s Heart Health Report newsletter, is chief of the Cardiac Transplant Program at the world-renowned Palm Beach Cardiovascular Clinic in Palm Beach Gardens, Fla. He practices interventional, vascular, and transplant cardiology. Dr. Crandall received his post-graduate training at Yale University School of Medicine, where he also completed three years of research in the Cardiovascular Surgery Division. Dr. Crandall regularly lectures nationally and internationally on preventive cardiology, cardiology healthcare of the elderly, healing, interventional cardiology, and heart transplants. Known as the “Christian physician,” Dr. Crandall has been heralded for his values and message of hope to all his heart patients.

Tags: pharmacogenetics | genetic testing | aspirin

Testing Genes for Drug Responses

Chauncey Crandall, M.D. By Wednesday, 23 November 2022 02:34 PM EST Current | Bio | Archive

Detecting inherited diseases isn’t the only purpose of genetic testing. There is also a field called “pharmacogenetics,” which looks at the role that genetics may play in a person’s response to a particular drug.

For instance, this is important for prescribing the anticlotting agent clopidogrel (Plavix) because as many as 30 percent of people have a genetic variant that prevents their liver from activating this drug. Therefore, they must take a higher dose or a different agent.

Aspirin resistance is another area of testing. Scientists have always wondered why aspirin, which helps reduce the risk of heart attack, is not effective for everyone.

We now know that as much as 45 percent of the population is genetically resistant to aspirin. Aspirin resistance is not yet routinely checked for, but that could change in the near future.

This is also an area that the FDA is watching carefully. The agency warned Inova Genomics Laboratory of Falls Church, Va., for illegally marketing genetic testing that had not been reviewed for this purpose.

The regulators were particularly concerned that patients may use these tests to start or stop taking particular treatments, decisions that they should only make in consultation with their doctor.

© 2023 NewsmaxHealth. All rights reserved.

There is a field called “pharmacogenetics,” which looks at the role that genetics may play in a person’s response to a particular drug.
pharmacogenetics, genetic testing, aspirin
Wednesday, 23 November 2022 02:34 PM
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