Tags: Diabetes | testosterone | therapy | low-t

Diabetics Benefit From Low-T Therapy: Study

Diabetics Benefit From Low-T Therapy: Study
(Copyright DPC)

By    |   Monday, 30 November 2015 10:30 PM

Men with Type 2 diabetes who have low testosterone levels benefit significantly from low-T therapy.

That’s the upshot of new research by University at Buffalo scientists who tracked the effects of testosterone treatment in 94 diabetic men on insulin resistance and inflammation, before and after treatment with testosterone.

The study, funded by the National Institutes of Health, was published online in the journal Diabetes Care.

"This is the first definitive evidence that testosterone is an insulin sensitizer and hence a metabolic hormone," said Dr. Paresh Dandona, a professor and chief of endocrinology, diabetes and metabolism in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at UB.

The UB researchers found that low testosterone levels were associated with decreased insulin sensitivity, a key a factor in diabetes.

"We hypothesized that testosterone may be an anti-inflammatory and insulin sensitizing agent since it has been known for some time that testosterone reduces adiposity and increases skeletal muscle," Dr. Dandona said. "Our previous work has shown that obesity is associated with oxidative stress and inflammation, and inflammatory mediators are known to interfere with insulin signaling."

In addition to boosting insulin sensitivity, low-T therapy also led to a reduction in total body fat and increased muscle mass by the same amount.

"Testosterone treatment for men, where indicated, will improve sexual function and increase skeletal muscle strength and bone density," added Dr. Dandona.

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Men with diabetes who have low testosterone levels benefit significantly from low-T therapy.
testosterone, therapy, low-t
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2015-30-30
Monday, 30 November 2015 10:30 PM
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