Tags: Digestive Problems | heartburn | drug | risks | warnings | ppi | proton

New Warnings on Heartburn Drugs

New Warnings on Heartburn Drugs
(Copyright DPC)

Friday, 05 February 2016 02:27 PM

Proton pump inhibitor medications — among the most frequently prescribed in the country — may pose an increased risk for kidney disease, new research suggests.

The study, published Johns Hopkins University researchers in JAMA Internal Medicine, tracked more than 260,000 patients in five states and found those who took prescription PPIs were 20 percent to 50 percent more likely to develop chronic kidney disease than nonusers, The New York Times reports. 

Dr. Morgan Grams, a nephrologist and epidemiologist at Johns Hopkins, noted the findings suggest an association between PPIs and kidney problems, but did not conclude that the drugs are necessarily the cause of the disease.

But risks were highest among those who took the drug twice daily, compared to those who took a daily dose.

 “That leads us to believe there’s a causal effect,” Dr. Grams said.

Since their introduction in 1990, the drugs collectively (common brand names: Nexium, Prevacid, Prilosec) have become among the most frequently prescribed in the country. They suppress stomach acid more effectively than a previous class of drugs called H2 blockers (Zantac, Tagamet, Pepcid).

But in recent years, scores of studies have reported associations between prescription PPI use and bone fractures, low magnesium levels, kidney injuries, and possibly cardiovascular drug interactions.

They are also linked to infections, like the stubborn Clostridium difficile and pneumonia. Reducing the acidity of the stomach, researchers believe, allows bacteria to thrive and then spread to other organs like the lungs and intestines.

Older people should probably pay special heed to the new findings, researchers said. They are more likely to have reflux, in part because the muscle that prevents stomach acid from rising into the esophagus weakens with age.

Older adults are therefore more likely to take these drugs, and also more vulnerable to the diseases and disorders associated with them in the long run.

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Proton pump inhibitor heartburn medications - among the most frequently prescribed in the country - may pose an increased risk for kidney disease, new research suggests.
heartburn, drug, risks, warnings, ppi, proton, pump, inhibitor
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2016-27-05
Friday, 05 February 2016 02:27 PM
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